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 Home > Available Issues |
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 Original Articles |
| Clinical Trials of Cefotetan |
| Hyun Jai Lee, Kyung Jin Yoo, Chun Ik Song, Dai Sik Hong, Yong Gwan Lee, Wan Shik Shin, Moon Won Kang, Hee Young Chung |
| Department of Internal Medicine, Catholic Medical College |
Vol.17 Num.2 (p173~179)
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The new cephamycin-type antibiotic, cefotetan is very stable to β-lactamase, it possesses a good antibacterial activity on aerobic and anaerobic gram-negative cocci and bacilli. Clinical values of cefotetan were evaluated in 26 patients with a clinical diagnosis of bacterial infection of the urinary, respiratory and gastrointestinal tract. The drug was administered intravenously in dose of 1~4g per day for 1 to 16 days. The clinical response was satisfactory in 11 (100%) patients with urinary tract infections, 8(61.5%) of 13 patients with respiratory tract infections, 2(100%) patients with gastrointestinal tract infections. Overall, cefotetan was effective in 21(80.8%) of all patients treated. During the treatment 5 patients showed adverse effects including nausea, diarrhea, skin rash, drug fever. And elevation of hepatic enzyme levels occured in 1 of all patients treated. But the majority of adverse effects disappeared within 2~3 days.
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