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 Original Articles |
| Clinical Studies on Sulbactam/Ampicillin |
| Se Hyun Cho, Sun Ha Kim, Wan Shik Shin, Moon Won Kang, Hee Young Chung |
| Department of Internal Medicine, Catholic University Medical College, Seoul, Korea |
Vol.20 Num.2 (p147~152)
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Sulbactam/Ampicillin (Unasyn?) is a combination drug of beta-lactam antibiotic, ampicillin, and beta-lactamase inhibitor, sulbactam.
Clinical study to observe the effect of sulbactam/ampicillin was done in 40 patients admitted at St. Mary's Hospital and St. Vincent's Hospital, on Catholic University Medical College.
1) Among the total of 40 patients, 16(94%) of 17 patients with urinary tract infection, 10(91%) of 11 patients with respiratory tract infection, 6(86%) of 7 patients with enteric fever, all of 4 patients with enterocolitis and one patient with bactermeia were clinically cured. It was effective in 37(92.5%) of 40 patients.
2) In 22 bacteriologically proved cases, 18 were eliminated, 1 of each were partially eliminated and peristent, and 2 were superinfected cases.
3) There was no particular side effect but 2 cases of indigestion, 1 case of eosinophilia and 1 case of elevated hepatic enzyme(SGPT) were developed.
4) Fifteen of the 22 isolated organisms were ampicillin-resistant, but all strains were sensitive to sulbactam/ampicillin.
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