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 Original Articles |
| In Vitro Susceptibility of 74 C. difficile isolates from Korean Patients to 13 Antibiotics |
| Kyung-Hee Kim |
| Department of Microbiology, Hanyang University College of Medicine Seoul, Korea |
Vol.20 Num.3 (p201~205)
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The in vitro susceptibilities of 74 isolates (seven from adults with antibiotic-associated colitis; 54 from diarrheagenic children; and 13 from normal controls) of C. difficile were investigated with 13 antimicrobial agents, including ampicillin, bacitracin, cephalothin, chloramphenicol, clindamycin, erythromycin, metronidazole, rifampin, tetracycline, trimethoprim, sulfamethoxazole, and vancomycin, Vancomycin and metronidazole were two most active agents (MIC90 for vancomycin, 1 μg/mL for all isolates and MIC90 for metronidazole, 0.25~1 μg/mL). All seven isolates from the adults with AAC were resistant to > 1024 μg of clindamycin per mL, whereas isolates from diarrheagenic children and the normal controls were variably resitant. All isolates of C. difficile were susceptible to low concentrations of ampicillin although most of the diarrheagenic children were suspected of developing ampicillin-associated diarrhea. Although bacitracin may be a useful altemative to vancomycin, more experience with this drug is needed in Korea beause most of our isolates required > 256 μg of bacitracin per mL for inhibition.
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