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 Original Articles |
| A Clinical Study on Cefixime in Respiratory Tract Infections |
| Moon Won Kang, Joo Hyun Park, Hyun Bock Han, Yang Ri Kim, Kwan Hyung Kim, Wan Shik Shin, Sung Hak Park |
| Department Internal Medicine, Catholic University Medical College, Seoul, Korea |
Vol.22 Num.3 (p151~155)
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Clinical efficacy and safety of cefixime, a new oral cephem antibiotics, were evaluated in 30 patients with respiratory tract infection.
Cefixime was administered to 30 cases consisting of 4 cases of acute tonsillitis, 16 cases of pneumonia (8/16 have underlying chronic lung disease) and 10 cases of acute exacerbation of chronic lung diseases (3 with bronchiectasis, 2 with bronchial asthma and 5 with chronic obstructive lung diseases), at daily dosis of 200~400mg for 5~21 days by oral route.
Clinical efficacy was evaluated to be excellent in 11 cases, good in 13 cases, fair in 5 cases and poor in 1 case. Thus cefixime was effective in 24 of 30 cases in total with a rate of effectiveness of 80%. Effectiveness of cefixime was 100% (12/12) in acute disease, but 66.7%(12/18) in chronic or complicated disease.
16 microorganisms were isolated from 13 cases. 10 cases were eradicated, 2 cases were persisted and 1 case was superinfected with P. aeruginosa.
Adverse resactions were found in 3 cases: 1 with eosinophilia, 1 with anorexia and 1 with eosinophilia and skin rash to whom cefixime was discontinued.
In conclusion, cefixime is useful oral drug for the empirical treatment of mild to moderate respiratory tract infection.
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