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 Original Articles |
| Cytomegalovirus Hepatitis in Infants: Detection of Cytomegalovirus Specific IgM Antibody in Sera and Virus Encoded Early Antigen in Urine |
| Young Mo Sohn, Hyeong Rae Joe, Soh Yeon Kim, Ki Sup Chung, Kyung Soon Song, Ki Keun Oh, Won Young Lee |
| Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea, Department of Clinical Pathology, Department of Radiology, Department of Microbiology |
Vol.22 Num.4 (p207~214)
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Four hundred and three infants with hepatosplenomegaly or abnormal liver function were studied for antibodies of Hepatitis A and B, Rubella, Herpes simplex virus, Cytomegalovirus (CMV), Toxoplasma and Syphilis. Among them, 22 infants were also studies for viruses in urine. Monoclonal antibodies especially, for that of CMV, were used to detect virus encoded early antigen with in the urine and the following results were obtained.
Among the 403 infants tested, 37 cases (9.2%) were confirmed CMV infection by detection of CMV specific IgM or viral antigen detection in urine. Among the 22 cases in which virus culture was done in urine, 8 cases (36.4%) were confirmed CMV infection and CMV was isolated in 6 cases (27.3%). Virus isolation rate of confimed CMV infected cases was 75% (6/8).
It can be concluded that hepatitis due to CMV plays a significant role in neonatal hepatitis in Korea.
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