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 Original Articles |
| In Vitro Activities of Meropenem, Imipenem and Ofloxacin Against Aerobic Gram-Negative Bacilli and Gram-Positive Cocci |
| Yunsop Chong1, Kyungwon Lee2, Samuel Y. Lee1 |
| Department of Clinical Pathology, Yonsei University College of Medicine, Seoul Korea1, and Department of Clinical Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea |
Vol.23 Num.2 (p95~105)
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In vitro antimicrobial activities of meropenem, imipenem and ofloxacin against aerobic gram-negative bacilli and gram-posititive cocci were compared to those of other antimicrobial agents. The strains were isolated from various clinical matarials in 1990 and the agar dilution method was used. In general, ampicillin, cefazolin and gentamicin were not very active. MIC90 of meropenem were ?0.06μg/ml against species of the Enterobacteriaceae other tham Enterobacter cloacae and Morganella morganii, against which the values were ?0.5μg/ml. The vaules against Pseudomonas aeruginosa and Acinetobacter anitratus were 2μg/ml. The values against methicilin-susceptible and resistant Staphylococcus aureus (MSSA and MRSA) were 0.12μg/ml and 32μg/ml, respectively. Meropenem was more active than imipenem against gram-negative bacilli. MIC90 of ofloxacin were against Enterobacteriaceae ?1 μg/ml, P. aeruginosa 32μg/ml and A. anitratus 0.5μg/ml. MIC90 of ofloxacin against both MSSA |
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