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 Original Articles |
| Haemophilus influenzae Isolated from Sputum Specimens: Prevalence, Biotypes and Antimicrobial Susceptibility |
| Yunsop Chong1, Kyung Soon Song1, Chik Hyun Pai2, Eui Chong Kim3, Tae Yeal Choi4 |
| Departments of Clinical Pathology, Yonsei University College of Medicine1, University of Ulsan College of Medicine2, Seoul National University College of Medicine3, and Hanyang University College of Medicine4, Seoul, Korea |
Vol.24 Num.2 (p107~113)
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Haemophilus influenzae, one of the normal flora of upper respiratory tract, may cause various infections. In this study, sputum specimens, taken mostly from eldery inpatients at 5 university hospitals in Seoul, during the August 1991 to January 1992 were cultured on vancomycin-bacitracin-clindamycin agar and 8.3% yielded H. influenzae. Among the isolates were: biotype I 41%; serotype b 4(1.4%) serotype a and c-f 3 (1.0%); β-lactamase producer 30.6%. Agar dilution test was performed with 52 β-lactamase-negative (HIV-) and 31 β-lactamase positive (BIB+) isolates. The ranges of minimum inhibitory concentration (MIC, in μg/mL) against HIB-/HIB+ were: ampicillin 0.25-1/4->128; cefaclor 0.5-8/1-16; cefadroxil 4-128/4-128; cephalexin 2-32/2-64; cephalothin 0.25-16/0.25-16; cephradine 4-64/4-128; erythromycin 1-32/2-32; tetracycline 0.25-16/0.25-32. Application of the breakpoints to the agar dilution test results showed that all of the HIB- were susceptible to ampicillin and cefaclor. All of the HIB+ were resistant to ampicillin, but 97% were susceptible to cefaclor. In conclusion, β-lactamase-positive strains became more frequently isolated, and both HIB+ and HIB- are often resistant to cefadroxil, cephalexin, cephradine and erythromycin, but mostly susceptible to cefaclor.
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