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 Original Articles |
| Inhibition Effect of Growth of Clostridium pereringens by Enterococcus faecalis |
| Wan Shik Shin, Jin Hong Yoo, Moon Won Kang, Sydney M. Finegold |
| Department of Internal Medicine, Catholic University Medical College, Seoul, Korea, Department of Internal Medicine, University of California, Los Angeles, U.S.A |
Vol.24 Num.2 (p93~98)
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It has known that some strains of Enterococcus faecalis inhibit some strains of enterococci and group D streptococcal species by production of enterocin. We found that Clostridium perfringens did not grow in our previous report of 'In vivo efficacy of cefotetan and cefoxitin in an intraabdominal abscess model in the mouse'. So we designed our experiments in vivo and in vitro to find out what bacteria inhibit the growth of C. perfringens.
The results were as follows;
1) C. perfringens from the intraabdominal and the subcutaneous abscess model using 5 bacterial isolates and autoclaved cecal content were not found. In vitro studies with various combination of organisms, C. perfringens did not grow in the groups of the co-culture with E. faecalis.
2) In vivo models using E. faecalis (106/mL) and C. perfringens (105/mL), we couldn't find any colonies of C. perfringens although we used a more concentration of C. perfringens than E. faecalis.
3) In direct and deferred antogonism test, inhibition zone to C. perfringens by E. faecalis was found, and more concentration of E. faecalis was necessary for inhibition of C. perfringens.
4) The inhibiton zone by E. faecalis filtrates using 0.22um filter was also found, but we couldn't see any inhibition when we diluted the E. faecalis filtrates.
5) C. septicum, C. cadaveris, and C. subterminale were inhibited by E. faecalis, whereas C. difficile, and C. sporogenes were not inhibited.
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