|
 |
 Home > Available Issues |
|
|
 Original Articles |
| Effect of Tosufloxacin in Urinary Tract Infection - Comparative Study with Norfloxacin- |
| Taik Hong Yun, Suk Ho So, Nak Gyeu Choi, Kyu Man Lee*, So Yung Shin** |
| Department of Urology, and Clinical Pathology*, College of Medicine, Hallym University and Lederle Laboratories**, Seoul, Korea |
Vol.24 Num.3 (p201~207)
|
|
|
In 82 patients enrolled in this study, 59 patients were clinically evaluable and 40 patients were bacteriologically evaluable.
Clinical effect of 59 patients (42 from Tosufloxacin (T) group and 17 from Norfloxacin (N) group) was evaulated and sensitivity test of 62 strains of micro-organism was tested with Tosufloxacin and Norfloxacin disc, in urinary tract infections. A 150 mg Tosufloxacin tablet was given two times daily to T group and a 200 mg Norfloxacin capsule was given three times daily to N group for 5 to 14 days according to the severity of urinary tract infection.
Clinical response of T group was 81.0% and that of N group was 64.7% and the clinical effect of 40 patients (30 from T group and 10 from N group) from whom the microorganism cultured before the treatment, were 90% and 70% respectively.
Of 82 patients, 40 patients (30 from T group, 10 from N group) were bacteriologically evaluable and eradication rate of Tosufloxacin and Norfloxacin were 96.7% and 90% respectively.
In the sensitivity test of 62 strains isolated from 82 patients, 82% were sensitive. 10% and 3% were resistant to Tosufloxacin and Norfloxacin disc respectively.
The clinical side effects were mild to moderate gastrointestinal in nature. There was no significant change in blood chemistry and other laboratory tests in both groups.
|
|
|
Keywords : |
|
|
|
|
|
|
|
|
