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 Original Articles |
| Changes of Varicella-zoster Specific Antibody Response after Live Attenuated Varicella Vaccine (Bikenⓡ) |
| Joseph Choi, Byoung Geun Lee, Pyoung Han Hwang, Jung Soo Kim |
| Department of Pediatrics, College of Medicine, Chonbuk National University, Chonju, Korea |
Vol.24 Num.3 (p209~214)
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Varicella is benign but highly contagious childhood disease.
Occasionally, it can be fatal, especially when it develops in children who have a severe underlying diseases or who have been treated with immunosuppressive drugs.
Unpredictable occurrence of varicella in hospitalized children has been troublesome for many years because subsequent cases inevitably follow after one case of varicella due to long incubation period and high infectivity even before the onset of symptoms. A live varicella vaccine (Biken?) developed by Takahashi has been tried for many years to reduce the occurrence and severity of varicella infection on healthy and immunocompromised children.
This study was designed to clarify the effect of Biken? on varicella-zoster specific antibody response. Changes of varicella-zoster specific IgG were measured using ELISA on the sera of children vaccinated by Biken.
The results were as follows:
1) After vaccination, the optical density of varicella-zoster specific IgG was significantly increased from 0.084±0.019 (p<0.01).
2) The values of varicella-zoster specific IgG in vaccinated group (0.18±0.019) were similar to those of varicella infected group (0.207±0.014), but lower than those of herpes zoster infected group (0.497±0.051).
3) The values of varicella-zoster specific IgG in mothers (0.157±0.038) were relatively higher than those of the infants (0.098±0.023).
These results sugest that live attenuated varicella vaccine (Biken?) can be used effectively for protection of varicella infection.
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