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Original Articles
Clinical Efficacy of Fluconazole in Oropharyngeal and Esophageal Candidiasis
Jong Dae Ji, Chul Won Choi, Goo Lee, Jae Myung Yoo, Woo Joo Kim, Jun Suk Kim, Seung Chull Park
Department of Internal Medicine, Guro Hospital, College of Medicine, Korea University, Seoul, Korea
Vol.24 Num.4 (p303~307)
The incidence of fungal infections has increased because of a number of factors such as increasing prevalence of immune-compromised hosts associated with organ transplantation and malignancies, and increasing use of broad-spectrum antibiotics, intravenous catheters, and hyperalimentation fluids.
Optimal therapies for fungal infections have not been defined. Amphotericin B is less than ideal because it is toxic, and can only be given intravenouslyl. Ketoconazole is hepatotoxic and is less effective in the treatment of systemic fungal infections. Fluconazole is a new, triazole antifungal agent which is proving to be effective in a wide range of fungal infections.
Clinical study of fluconazole was undertaken to total 20 patients with oropharyngeal and esophageal candidiasis. Oral or intravenous fluconazole 50 to 100 mg once or twice daily were administerd. 17(85%) of 20 patients responded favorably to treatment and no adverse reactions occured. Mean duration of drug administration was 8.8±2.8 days and mean amount of drug administered was 955+627 mg.
In conclusion, fluconazole is effective drug in the treatment of oropharygeal and esophageal candidiasis.
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