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 Original Articles |
| Clinical Efficacy of Teicoplanin in Gram-Positive Bacterial Infection |
| Kang Hyeon Choe, Jae-Hoon Song, Goo Yeong Cho, Hyung Ho Kim, Bin Yoo, Cheolwon Suh, Chik Hyun Pai* |
| Department of Internal Medicine and Clinical Pathology* Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea |
Vol.25 Num.1 (p57~62)
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Backgrounds: Gram-positive cocci have been an increasing cause of nosocomial infections in recent years. Treatment of these infections is often difficult, particularly infections by methicillin-resistant Staphylococcus aureus (MRSA). Teicoplanin, a new glycopeptide antibiotic, has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. To evaluate the clinical efficacy of teicoplanin in the treatment of patients with gram-positive bacterial infection and to compare the in vitro susceptibility of teicoplanin with other antimicrobials, we performed a prospective open trial of teicoplanin.
Methods: Twenty patients with infections by garm-positive organism were enrolled. The patients were received 400mg of teicoplanin followed by 200mg from next day as maintenance dose. During the follow-up period, clinical features and laboratory parameters were ckecked to evaluate clinical efficacy and appropriate cultures were followed to determine the microbiologic efficacy. The adverse effects of teicoplanin were also observed.
Results: The enrolled patients were 16 males and 4 females, whose mean age was 51±13 years. The categories of infections were bacteremia (5), skin and soft tissue infection (4), empyema (3), UTI (2), pneumonia (1), catheter associated infection (1) and infective endocarditis (1). The etiologic organisms isolated were MRSA (9), coagulase-negative Staphlyococcus (5), S. viridans (2), Group D streptococcus (2), S. pneumoniae (1), and E. faecalis (1). All 20 patients treated with teicoplanin showed clinical cure (13/20) or clinical improvement (7/20), whereas 90% of isolated organisms were eradicated after teicoplanin therapy. The adverse effect of teicoplanin was minimal.
Conclusion: Teicoplanin is safe and effective in the therapy of many different infections caused by gram-positive oragnisms.
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