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 Original Articles |
| CD4＋T Lymphocyte, β2-Microglobulin and p24 antigen Level in HIV Infected Persons |
| Young Keol Cho, Byung Sun Choi, Young Bong Kim, Goon Jae Cho*, Chun Kang, Sung Soon Kim, Mee Kyung Kee, Sook Jin Hur, Tae Sook Kim, Yang Ja Cho**, Yung Oh Shin |
| Center for AIDS Research, National Institute of Health, Seoul, Korea
Department of Internal Medicine*, Pusan National University Hospital, Pusan, Korea
Department of Microbiology, College of Medicine, Hanyang Univ. Seoul, Korea |
Vol.25 Num.2 (p139~149)
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We have measured CD4＋T lymphocyte, β2-microglobulin(β2-MG) and p24 antigen level in 188 HIV patients. Estimated duration from presumptive HIV infection to last tested CD4＋T lymphocyte counting was 55.2±23 months in group with Zidovudine (Acidothymidine, AZT) treatment (Tx) and 38.4±20 months in group without AZT. There was no CD4＋T lymphocyte of less than 400/mm3 in 56 normal persons but 46% (86) were CD4＋T lymphocyte of less than 400/mm3 in 188 HIV patients. Annual decrease of CD4＋T lymphocyte counts was 70/mm3 in group without AZT tx and 38/mm3 in group with AZT tx 15.2 months after tx start. In the distribution of serum β2-MG level in 182 HIV patients and 48 normal control, 90% (43) of control were below 2.0 mg/L and 76% (139) of HIV patients were over 2.0 mg/L (p = 0). β2-MG level was negatively correlated with CD4＋T lymphocyte (r = -0.394, p ＜ 0.001). HIV p24 core antigen was detected in 26 (14.9%) out of 174 HIV/AIDS patients. Of the 26 patients, 21 (81%) were CD4＋T lymphocyte of less than 400/mm3 and 46% (12) of less than 200/mm3. It was confirmed that 3 tests mentioned above are useful markers for prognosis of HIV infected persons.
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