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 Original Articles |
| Change of Serum β2-Microglobulin, p24 Antigen and CD4＋ T Lymphocyte in Persons with Human Immunodeficiency Virus Infection after Azidothymidine Treatment |
| Young Keol Cho, Yoo Kyum Kim, Young Oh Shin*, Yang Ja Cho** |
| Department of Microbiology, College of Medicine, Ulsan University, Seoul, Korea
Center for AIDS Research, National Institute of Health*, Seoul, Korea
Department of Microbiology, College of Medicine, Hanyang University**, Seoul, Korea |
Vol.25 Num.3 (p211~219)
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The effect of azidothymidine (AZT) in 48 HIV-infected patients taking AZT was evaluated by CD4＋ T lymphocyte counts, serum β2-Microglobulin (β2-MG). and p24 antigen levels. The results were also compared with the group without AZT. Annual decrease of CD4＋ T lymphocyte counts was 70 cells/μL in group without AZT Tx and 38 cells/μL in group with AZT Tx. Response rate of CD4＋ T lymphocyte counts to AZT Tx was 77% within 2 mon손, 68% within 2 to 6 months, 41% within 6 to 12 months and 31% within 12 to 24 months after AZT Tx. The level of β2-MG dropped from 2.95±1.45 mg/L at 2.2 months before Tx to 2.87±0.9 mg/L at 2.4 months after Tx, and then increased to 3.05±1.11 mg/L at 7.4±4.4 months after AZT Tx. HIV p24 antigen was detected in 26(14.9%) of 174 persons with HIV infection. p24 antigen level tested within 2 months after AZT Tx decreased in 9(69%) of 13 patients receiving Tx. And p24 antigen level showed significant decrease from 11.2±11.2 pg/mL to 5.6±3.2 pg/mL at 1.8±0.8 months after AZT Tx(p＜0.01) and then increase to 18.4±18.5 pg/mL at 6.2±3.2 months after Tx (p＜0.01). The data indicate that drug resistance to AZT gradually develops within one year after AZT Tx.
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