|
 |
 Home > Available Issues |
|
|
 Original Articles |
| Teicoplanin Plus Aminoglycoside Therapy in Febrile Granulocytopenic Patients |
| Jeong Hee Kim, Joon Sik Kim, Wan Gyu Uh, Si Young Kim, Hwi Joong Yoon, Kyung Sam Cho |
| Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea |
Vol.25 Num.3 (p231~237)
|
|
|
Infections with Gram-positive micro-orgamisms are an increasing cause of morbidity and mortality in granulocytopenic patients. Teicoplanin is a new glycopeptide antibiotic, chemically related to vancomycin. Teicoplanin has the same antibacterial spectrum of vancomycin with the added advantage of a long half-life, allowing once-a-day administration.
The clinical efficacy of teicoplanin and aminoglycoside combination as initial empiric antibiotic therapy was evaluated in 20 febrile granulocytopenic patients. Clinical response rate was 70% (14/20). Microbiologically documented infections accounte for 40% (8/20). Microbiologic response rate was 67% for G (+) and 40% for G (-) infection. No severe side effects were documented in any patient.
In conclusion, Teicoplanin is a safe and effective anti-gram-positive agent as an empiric therapy in febrile granulocytopenic patients.
|
|
|
Keywords : |
|
|
|
|
|
|
|
|
