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 Original Articles |
| The Efficacy of Timentin in the Treatment of Patients with Lower Respiratory Tract Infection |
| Heung Jeong Woo, Jong Dae Ji, Hyeon Jai Shin, Woo Joo Kim, Kwang Ho In, Min Ja Kim, Se Wha Yoo, Seung Chull Park |
| Department of Internal Medicine, Korea University, College of Medicine, Seoul, Korea |
Vol.25 Num.4 (p369~374)
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The combination of ticarcillin and clavulanic acid (Timentin) was used in a non-randomized open study in 30 patients with lower respiratory tract infection to assess the clinical efficacy and safety of the drug. The clinical diagnosis were: pneumonia (26), lung abscess (2), chronic bronchitis (1), and acute exacerbation of chronic obstructive pulmonary disease (1). Timentin 3.2 g were administered every 6 or 8 hours for a mean duration of 10.6 days (range 3~20 days). Timentin was clinically effective treatment in 23 (79%) of 29 evaluable patients. The isolated pathogens were P. aeruginosa (7), K. pneumoniae (3), S. pneumoniae (3), S. aureus (2), E. aerogence (2) and other organisms (5). Four patients with infection due to P. aeruginosa were failed. Infection due to other organisms except P. aeruginosa were 14 cases and showed high cure rate of 86% (12/14). Adverse effects were reported from 3 patients: one drug fever, one urticaria and one mild elevation of transaminases.
This open study shows Timentin to be a safe and effective antibiotic for the treatment of the lower respiratory tract infection.
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