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 Original Articles |
| In vitro Activities of Loracarbef Against Major Etiologic Species of Bacteria Causing Respiratory, Skin and Urinary Tract Infections |
| Yunsop Chong, Kyungwon Lee, Oh Hun Kwon |
| Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea |
Vol.26 Num.1 (p73~79)
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Activities of loracarbef, against the species of bacteria commonly causing community-acquired respiratory, skin and urinary tract infections, were determined by the agar dilution test. Hovever, the strains used were mostly isolated from inpatients, not from outpatients. MIC ranges (in μg/mL) of loracarbef were: ≤0.12 against S. pyogenes, 1~2 against S. agalactiae, 1~4 against penicillin G (PEN)-susceptible S. aureus, 1~8 against PEN-resistant S. aureus, ≤0.12 against PEN-susceptible coagulase-negative staphylococci (CNS) and 0.5~8 against PEN-resistant CNS, 0.5~8 against M.(B.) catarrhalis, 2~16 against β-lactamase(BL)-positive H. infuluenzae, 0.5~8 against BL-negative H. influenzae, 0.25~2 against E. coli and P. mirabilis and 0.5~64 against K. pneumoniae. Except 5% of K. pneumoniae, all of the other strains were interpreted to be susceptible to loracarbef. The resistance rates to amoxicillin were: 100% of PEN-resistant staphylococci, 95% of M.(B.) catarrhalis, all of BL-positive H. influenzae and K. pneumoniae, 90% of E. coli and 32% of P. mirabilis. It is concluded that the in vitro susceptibility indicates the usefulness of loracarbef for the treatment of most of the community-acquired respiratory, skin and urinary tract infections.
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Keywords : In vitro activities, Loracarbef, Respiratory, Skin and urinary pathogens |
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