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 Original Articles |
| Clinical Characteristics and Antimicrobial Susceptibility of Biliary Bacteria |
| Cheol Whan Lee, Geun Chan Lee, Yang Soo Kim, Sung Goo Lee, Jae-Hoon Song, Myung Hwan Kim, Young Il Min |
| Department of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea |
Vol.26 Num.1 (p81~85)
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During a three-year period, 600 patients were admitted to the Asan Medical Center because of biliary tract diseases. Both aerobic and anaerobic cultures were performed in 313 patients with cholangitis (bile: 253, blood: 113, both: 53). Of these patients, 189 were positive(bile 159. blood 68. both 38). The most common organisms were E. coli, K pneumoniae, and P. aeruginosa in both bile(respectively, 49.7%, 20.8%, 51.5%) and blood cultures(respectively, 45.6%, 26.5%, 22.1%). Anaerobes were present in 1.5% of positive blood cultures and 1.3% of positive bile cultures. Antibiotic therapy did not sterilize bile, but selectively increased the proportions of P.aeruginosa. There was no significant difference in biliary bacteriology according to the history of biliary surgery, or the presence of percutaneous biliary drainage or underlying disease. More than 95% of gram-negative organisms isolated was highly susceptible to imipenem and amikacin. P. aeruginosa was resistant to ceftazidime in 63.3% which might be associated with overuse of the drug during the study period. Further studies will be necessary in patients with cholangitis to determine whether newer antibiotics replace previous combination therapy.
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Keywords : Billiary bacteria, Antimicrobial susceptibility |
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