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 Original Articles |
| Clinical and Serological Studies of Measles during Measles Epidemics in Taejeon |
| shin Hye Moon, Hong Ryang kil, Jae Hong Yu, Keon Su Rhee, Young Hun Chung, Jae Ho Lee, Jae Won Chung,*, Ji Whan Han*, Sung Su Hwang*, Ha Shin Park**, Hye Jin Choeh**, Jin Ki Chung***, Yun Duk Yu*** |
| Department of Pediatrics, College of Medicine, Chungnam National University and College of Medicine, Catholic University* and Eulji General Hospital** and Sun General Hospital*** Taejeon, Korea |
Vol.26 Num.2 (p125~132)
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A clinical study was made on 133 case of measles patients during epidemics in Taejeon from Nov. 1993 to Jan. 1994. The patients were divided into four groups by vaccination history. We evaluated the clinical manifestations, complications, and serological antibody of measles (IgM & IgG) in each group.
The results were summerized as follows.
1) Out of 133 patients, 71 patients(53.4%) were the vaccinated group and 62 patients(46.6%) were the unvaccinated group. Peak ages of measles in each group were 5~8 year old(64.7%) in Group I, less than 2 year old(70%) in Group II, more than 6 year old(80%) in Group III, and less than 1 year old(80.6%) in Group IV.
2) Fever developed before 2 days of rash appearence(45.1%) and at the same time(32.3%). Duration of fever was less than 3 days in 46 cases(34.6%).
3) All patients had cough and 80 cases(60.2%) had cough more than 10 days. Cough continued more than 10 days in 42 cases(67.7%) of 62 unvaccinated cases and 38 cases(53.5%) of 71 vaccinated cases.
4) Complications such as pneumonia, otitis media, gastroenteritis, and hepatitis were noted in 66.1% of all patients and most common in Group IV.
5) In the 64 patients of vaccinated group carried out serologic test, measles specific IgM antibodies were positive in 85.9%(primary vaccine failure) and negative in 14.1% (secondary vaccine failure). In the 53 patients of unvaccinated group carried out serologic test, measles specific IgG antibodies were negative in 37.7%, less than 14 month old.
In conclusion, primary vaccine faliure(85.9%) was the main cause of measles during epidemics in the vaccinated group. Maternal measles IgG antibodies were not detected in 37.7%, less than 14 month old.
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Keywords : Measles, Vaccination, Primary vaccine failure, Measles IgM & IgG |
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