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 Original Articles |
| Invasive Candidiasis in Children |
| Mi Ran Kim, Hoan Jong Lee |
| Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea |
Vol.26 Num.2 (p155~163)
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In the last decade, documented fungal infections has been increased in immunocompromised host. We reviewed 47 cases of invasive candidiasis in children diagnosed at Seoul National University Children's Hospital from Oct. 1985 to Jul. 1993. The results are as follows. The categories of invasive candidiasis were 40 cases of candidemia with focal infections in 27, 3 cases of meningitis, 2 cases of biopsy-confirmed cutaneous nodules, 1 case of peritonitis, and 1 case of osteoarthritis. The cases of invasive candidiasis increased annually and 93% was nosocomially acquired. All of the cases had underlying diseases. Isolated candida spp. were C. albicans 79%, C. parapsilosis 11%, C. tropicalis 6%, and C. glabrata 4%. The risk factors perceding invasive candidiasis were peripheral intravenous lines 100% , antibiotic therapy 91%, malnutrition 79%, parenteral hyperalimentation 60%, central venous catheter 58%, nasogastric tube 56%, ventilator 51%, recent surgery 47%, and bacterial infections 40%, etc. 11 of 40 cases evaluable died without recovery from invasive candidiasis, and amphotericin B was used in 23 patients but did not affect recovery significantly. In conclusion, invasive candidiasis was increasingly recognized and every efforts should be made to make early diagnosis and treatment in the high risk children by high index of suspicion considering the high mortality.
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Keywords : Candida, Invasive candidiasis, Immunocompromised host |
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