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 Original Articles |
| Immunogenicity and Safety of a 23-valent Pneumococcal Polysaccharide Vaccine in Healthy Children and in Children at Increased Risk of Pneumococcal Infection |
| Seong Hee Jang*, Hoan Jong Lee, Hee Young Shin, Hyo Seop Ahn, Yong Choi |
| Department of Pediatrics, Kangnam General Hospital Public Co*; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea |
Vol.26 Num.3 (p217~227)
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The antibody response to a 23-valent pneumococcal polysaccharide vaccine was studied in 21 healthy, 48 nephrotic and 29 splenectomized children. Antibody levels before and 4 weeks after immunization against the six pneumococcal serotypes(6B, 9V, 14, 18C, 19F and 23F) were determined by an enzyme-linked immunosorbent assay. The healthy children responded well to vaccination with a mean fold increase of 2.6 in postvaccination antibody titers compared to prevaccination titers. In children with nephrotic syndrome and splenectomized children an antibody response did not differ significantly from that of healthy children. Howerer, they had significantly lower geometric mean antibody titers for some antigens both before and after immunization. Adverse reactions were always mild and transient, consisting of local pain and/or erythema or swelling in 41% and fever above 38.5℃ in 3% of the children these results indicate that pneumococcal polysaccharide vaccine is immunogenic and safe in high-risk as well as healthy children.
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Keywords : Streptococcus pneumoniae, pneumoccoccal antibody, pneumococcal vaccine, splenectomy, nephrotic syndrome |
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