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 Home > Available Issues |
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 Original Articles |
| Antimicrobial Resistance and Plasmid Profile of Methicillin-Resistant Staphylococcus aureus |
| Phil Youl Ryu1), Young-Il Kim1), Jun Haeng Rhee1), Sun Sik Chung1), Tai Hew Ahn1), Jong Hee Shin2), Dong Wook Ryang2), Young Hyu Kim3) |
| Department of Microbiology1), Department of Clinical Pathology2), Chonnam University Medical School, Department of Clinical Pathology3), Kwangju Christian Hospital, Kwangju, Korea |
Vol.27 Num.1 (p15~29)
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Background : Increased isolation of methicillin-resistant Straphylococcus aureus has become one of the most important problem in treating staphylococcal infections. The aim of the study was to investigate the epidemiological characteristics of antimicrobial resistance of MRSA's isolated in the Kwangju area.
Methods : 251 strains of S. aureus were isolated from various specimens from A-hospital and B-hospital and their resistance patterns against 19 antimicrobial agents and plasmid profiles studies.
Results : Methicillin resistance was detected in 74.2% and 46.1% of A-hospital and B-hospital isolates, respectively. Resistance to cephalosporins and aminoglycosides was more frequent in the A-hospital isolates than in the B-hospital isolates, whereas fosfomycin resistance was more frequent in the B-hospital isolates than in the A-hospital isolates. Frequency of resistance to ampicillin, tetracycline, chloramphenicol, ciprofloxacin in A-hospital isolates was similar to B-hospital isolates. Strains with multiple resistance to more than 10 drugs were more frequent in the A-hospital isolates than that in the B-hospital isolates. Among MRSA strains, resistance to netilmicin and rifampin was more frequently encountered in A-hospital isolates, while resistance to fosfomycin, tetracyclin, and chloramphenicol was more frequent in B-hospital isolates. No differences in resistance patterns against other cephalosporins and aminoglycosides were observed between the two hospitals. Fosfomycin, chloramphenicol and rifampin resistances were different between the two hospitals in strains with multiple resistance. The most frequently observed multiple resistance patterns observed among A-hospital isolates were AmcCtxCzolLmoxGmTobLcmAmkNetTcEmRfp and AmcCtxCzolCmdlLmoxFomGmTobLcmAmkNetTcEmRfp. Among B-hospital Isolates, AmcCtxCzolLmoxFomGmTob-LcmAmkChpTcEm pattern was the most frequent.
Conclusion : MRSA strains from both hospitals showed cross-resistance to β-lactams and aminoglycosides. Plasmid profiles from MRSA strains were different, according to the multiple resistance patterns. Characteristically, 108 kb plasmid was detected only in A-hospital-MRSA strains, while 2.8 kb plasmid was detected only in B-hospital-MRSA strains.
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Keywords : MRSA, Plasmid profile, Antimicrobial resistance |
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