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 Original Articles |
| Therapeutic Efficacy of Ciclopirox Nail Lacquer in the Treatment of Onychomycosis |
| Byung-Su Kim, Kyoung-Chan Park, Jeong-Aee Kim, Hyung-Don Bang, Kwang-Hyun Cho, Jai-Il Youn |
| Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea |
Vol.27 Num.3 (p261~266)
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Background : Topical antifungal agents have been ineffective in the treatment of onychomycosis because they could not reach the infected nail bed. 8% ciclopirox nail lacquer is a new topical antimycotic which is characterized by excellent penetration into the nail plate. We performed a study to assess the therapeutic efficacy and safety of 8% ciclopirox nail lacquer in the treatment of onychomycosis.
Methods : We assessed 27 onychomycotic patients whose affected area of target nail plate was not more than 50%. The patients were instructed to apply 8% ciclopirox nail lacquer once daily and evaluated monthly for 6 months. Mycological examinations were done before and after the treatment. Overall efficacy, tolerability, cometic acceptance and adverse effects were assessed at the end of 6 month's treatment.
Results : The mean percentage of affected area decreased from 28.9% to 4.7%. Mycological cure rate was 77.8% at the end of the treatment. Overall efficacy assessed by physician and patients were similar and evaluated as complete cure in 48% and 44%, respectively. Tolerability and cosmetic acceptance were excellent or good in most of the patients. No systemic adverse effects were found, but 3 patients complained of mild prickling sensation or ingrowing toe nail.
Conclusions : These data suggest that 8% ciclopirox nail lacquer is safe and effective in the treatment of mild onychomycosis.
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Keywords : ciclopirox, nail lacquer, onychomycosis |
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