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Original Articles
Cefepime Susceptibility of Aerobic Gram-negative Bacilli Isolated From a General Hospital Patients
Yunsop Chong, Kyungwon Lee, Oh Hun Kwon
Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea
Vol.27 Num.5 (p461~467)
Background : Previous agar dilution test showed that cefepime is very active against various gram-nagative bacilli including the third generation cephalosporin-resistant Enter-obacter, Serratia and Citrobacter. The aim of this study was to test the susceptibility of large number of recent clinical isolates of gram-negative bacilli to cefepime.
Methods : A total of 4797 isolates of Enterobacteriaceae, Aeromonas, Pseudomonas aeruginosa, Acinetobacter baumannii and Xanthomonas maltophilia isolated from a tertiary-care general hospital patients, were tested by the NCCLS disk kiffusion test and the results were analyzed using a WHONET III program.
Results : Resistance rates of Enterobacteriaceae were 82% to ampicillin, 71% to cephalothin, 24% to gentamicin, 10% to ofloxacin, 15 to cefotaxime, 7% to cefoperazone/sulbactam and 1% to cefepime. P. aeruginosa showed the lowest resistance rate of 24% to both cefepime and ceftazidime. The cefepime susceptible rates of cefotaxime-resistant isolates were C. freundii 77%, E. cloacae 61% and S. marcescens 53%.
Conclusion : Resistance rates of the recent clinical isolates of aerobic gram-negative bacilli, including the third generation cephalosporin-resistant nosocomial pathogens, are lower to cefepime than to the other antimicrobial agents compared.
Keywords : Cefepime, Nosocomial pathogen, Antimicrobial susceptibility, Enterobacter