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 Case Reports |
| Two Cases of Hepatosplenic Candidiasis in Children with Acute Leukemia |
| Yun Kyoung Lee, Eun Hwa Choi, Jin Young Park, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn |
| Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea |
Vol.27 Num.6 (p565~570)
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Although intensive chemotherapy for malignant diseases can prolong the survival, it also induces profound immunosuppression and increase the risk of serious fungal infections. Candida albicans is the most common cause of systemic fungal infections and hepatosplenic candidiasis has been increasingly recognized as a variant of disseminated candidiasis among immunocompromised hosts. We have experienced two cases of hepatosplenic candidiasis in children with acute leukemia. They presented recurrent fever and hepatosplenomegaly after recovery from neutropenia. Characteristic 'target' lesions in the liver, spleen, and kidneys were noted on abdominal ultrasonography. Each case was confirmed by culture of blood or liver aspirates, respectively. Both were treated successfully with amphotericin-B in combination with fluconazole. Hepatosplenic candidiasis is considered as one of the important causes of fever unresponsive to empirical antimicrobial therapy in patients with prolonged neutropenia. Therefore, empirical antifungal therapy should be given to suspicious cases.
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Keywords : Candidiasis, Neutropenia, liver, Spleen |
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