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 Original Articles |
| Trend of Passive Measles Specific IgG Antibody in Infants below 10 Months of Age |
| Ki Young Jang, Young Kyoo Shin, Ji Tae Choungk, Young Chang Tockgo, Yong Ju Lee* |
| Department of Pediatrics and Microbiology*, College of Medicine, Korea University, Seoul, Korea |
Vol.28 Num.1 (p51~57)
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Background : Despite preventive measures, measles outbreaks occurred in 1989, 1990 and 1994 in Korea. Of the measles patients, the proportion of young infants below 15 month of age was high in those outbreaks. We assume that the reason might be fast decrement of the level of maternally derived measles specific IgG antibody in young infants. We attempted to demonstrate the decreasing trend of the transplacentally transferred passive measles antibody concentration in young infants by measuring the measles specific IgG antibody levels in neonates and unvaccinated infants younger than 10 months of age.
Methods : From Oct. 1 1994 to Mar. 31 1995 we collected the sera from 44 meonates (umbilical cord) and 91 unvaccinated infants younger than 10 months of age cared at Anam hospital of Korea university medical cencer. These infants were not immunocompromised and had no history of natural measles. We measured the measles specific IgG antibody using enzyme linked immunosorbent assay (ELISA: Sigma Diagnostics, SIATM Measles IgG Kit).
Results : The seropositivity and level of measles specific IgG antibody decreased with the age of infants, 76.5% of 0~1 month of age, 23.8% in 6~7 months of age and3.6% in 8~9 months of age. There was significant relationship between measles specific IgG antibody level and the age of infants (measles specific IgG antibody level = -0.572 × age(day) + 185, r = -0.5409, p＜0.001).
Conclusion : Decrement of measles specific IgG antibody was responsible for recent measles partly in young infants. We suggest that current immunization program for measles in Korea needs to be modified.
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Keywords : Measles, IgG antibody titer, Infant |
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