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 Original Articles |
| Immune Response to Hepatitis B Revaccination |
| Seong Ja Lee, Hae Kyung Han, Mi Ryung Um, Kyung Hoon Choi, Mi Na Lee, Byung Hun Yoo |
| Department of Pediatrics, Cheil Hospital, Chung-Ang University College of Medicine*, Seoul, Korea |
Vol.28 Num.1 (p59~66)
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Background : The seroconversion rate of hepatitis B after three consecutive vaccinations is estimated to be approximately 90%. We have given booster injections to the seronegative childern with the fourth, fifth or sixth vaccination and estimated the seroconversion rate of hepatitis B (Hepavax? : Korean Green Cross Corporation) in relation to the number of vaccination.
Methods : Serum samples were obtained from 934 babies who visited Cheil Hospital at 9 months of age (3 months after the 3rd vaccination) to determine the presence of HBsAg and titer of anti-HBs. The cases of negative anti-HBs were given a booster dose and anti-HBs titer was tested 4 weeks later. The babies who still had negative anti-HBs after the 4th dose were given the 5th and the 6th doses and anti-BHs titer was tested. RIA (Abbott Laboratories, U.S.A.) was used to determine the titers of anti-HBs. Seventy-eight Babies Born to Mothers who were HBsAg-positive were tested for HBsAg and titers of anti-HBs at 3 months of age after the 2nd vaccination.
Results : 1) Twenty-two babies out of 64(34.9%) showed seroconversion after the 2nd vaccination. Six hundred babies out of 893(67.2%) showed seroconversion after the 3rd vaccination. Among the babies who were given the 4th dose 101 out of 172 (58.7%) babies showed seroconversion and for the 6th dose 4 out of 13 babies.
2) Cumulative seroconversion rate was 90.8% and 98.7% after the 4th and 6th vaccination, respectively.
3) The geometric mean titer (GMT) of anti-HBs was 19.2mIU/mL after the 2nd vaccination, 112.7mIU/mL after the 3rd vaccination and 57.1mIU/mL after the 4th vaccination.
Conclusion : Seroconversion rate increased after the 4th dose for the babies who had negative anti-HBs even after the 3rd vaccination. Therefore, we recommend to screen for anti-HBs after the 3rd vaccination and to give booster injections for those who are negative anti-HBs.
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Keywords : Hepatitis B vaccine, Seroconversion rate, Booster |
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