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A Case of Type 2 Herpes Simplex Virus Meningitis
Nam Joong Kim, Young Joo Park, Eun Bong Lee, Hyoung Shik Shin, Hee Jung Choi, Hong Bin Kim, Sang Won Park, Eui Chong Kim*, Kang Won Choe
Department of Internal Medicine and Clinical Pathology*, College of Medicine, Seoul National University, Seoul, Korea
Vol.28 Num.3 (p283~288)
Herpes simplex virus(HSV) meningitis is generally Due to Type 2 HSV(HSV-2) and occurs especially in young, sexually active adults. HSV meningitis, usually seen in association with primary genital HSV infection, is an self-limited disease manifested by headache, fever, and mild photophobia, which last from two to seven days. A lymphocytic pleocytosis in the cerebrospinal fluid is characteristic. Viral culture of the cerebrospinal fluid is sometimes negative, especially in cases of recurrent disease. The failure of culture technique has led to the use of new diagnostic technique such as polymerase chain reaction(PCR).
We report a case of HSV-2 meningitis in young woman who presented with headache and fever. With the use of the PCR, HSV-2 DNA was detected in cerebrospinal fluid and vesicular fluid from the patient. Symptoms of meningeal irritation subsided spontaneously with supportive care.

Keywords : Type 2 Herpes Simplex Virus, Meningitis