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 Original Articles |
| Clinical Course and Prognostic Factors of Enterobacter Bacteremia |
| Il Woo Jung, Wook Sun Choi, Seung Jae Hong, Sung Bae Lee, Chong Oh Park, Koo Yeop Kim, Hee Zoo Lee*, Hwan Jo Seo |
| Department of Internal Medicine and Clinical Pathology, Kyung-Hee University School of Medicine, Seoul, Korea |
Vol.28 Num.5 (p437~441)
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Background : Enterobacter species have emerged as important human pathogens, particularly in hospitalized patients. Recently, the morbidity and mortality associated with Enterobacter bacteremia have increased. sick because popalativn of old ages, neoplasms., use of indwelling catheter, use of antibiotics and organ transplantations have increased, In this study the epidemiologic factors, clinical characteristics, treatment and outcome of 49 patients with Enterobacter bacteremia are reviewed in Kyung-Hee medical center during a 5-year period.
Methods : Fourty-nine cases of Enterobacter bacteremia diagnosed from January 1990 to December 1994 in Kyunghee medical center were analysed by their clinical records retrospectively.
Results :
1) Male to female ratio was 1.72:1 and mean age was 39.1.
2) twenty-nine cases were nosocomially acquired; Enterobacter bacteremia six showed polymicrobial infections.
3) Significant underlying conditions were present in 46 patients(93.85%), and the respiratory tract infection was the most common source of bacteremia.
4) Common clinical manifestations were fever(75.5%), leukocytosis(46.9%) and thrombocytopenia(34.6%), and there were no symptom discrimating from or signs bacteremias by other gram negative organisms.
5) In vitro tests showed susceptibility rates of 89.9% to amikacin, 87.5% to ciprofloxacine, 4.2% to ampicillin and 6.2% to cephalothin.
6) Case fatality rate was 30.6% and the mortality was significantly increased with the presence of pneumonia, septic shock or other fatal underlying diseases.
Conclusion : This study suggests that Enterobacter bacteremia is common in patients with altered host defenses secondary to serious underlying disease. Appropriate antibiotics are necessary to decrease the morbidity and mortality rates in enterobacter bacteremia with fatal underlying disease.
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Keywords : Enterobacter, Bacteremia |
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