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 Original Articles |
| Vancomycin-Gentamicin Synergism against Methicillin-resistant
Staphylococcus aureus:Relationship with Gentamicin Susceptibility |
| Eun Ok Kim, M.D., Yang Soo Kim, M.D., Baek Nam Kim, M.D.,
Su Jin Park,2 Sang-Oh Lee, M.D., Doo Ryeon Chung, M.D., Mi Na Kim, M.D.1,
Jun Hee Woo, M.D., Chik Hyun Pay, M.D.1 and Ji So Ryu, M.D. |
| Department of Internal Medicine, Department of Clinical Pathology1, Asan Medical Center,
University of Ulsan College of Medicine; Asan institute for life sciences2, Seoul, Korea |
Vol.30 Num.2 (p156~164)
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Background:Vancomycin is the drug of choice for the treatment of infections caused by methicillin- resistant Staphylococcus aureus(MRSA). However, vancomycin monotherapy of deep-seated staphylococcal infection may be associated with poor bacteriological response. Limited data suggest that vancomycin- gentamicin combination therapy is effective against MRSA. In this study, we evaluated the vancomycin- gentamicin synergism against MRSA and also investigated whether gentamicin susceptibility may affect the synergism.
Materials and Methods:The 51 strains of MRSA were obtained from patients at the Asan Medical Center from 1995 to 1996. The minimal inhibitory concentrations(MICs) of gentamicin were determined by the agar dilution method. The 25 strains with various levels of gentamicin MICs were chosen for time-kill studies. The MICs and minimal bactericidal concentrations(MBCs) of vancomycin were defined to ? |
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Keywords : MRSA, MICs of gentamicin, vancomycin-gentamicin synergism |
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