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 Original Articles |
| Pseudoinfections Due to Benzalconium-chloride Solution Contaminated with Burkholderia cepacia |
| Kye Seon Yoo/Sang Hwa Kim/In Kyung Jung/Hwan Jo Suh |
| Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea. Infection Control Office, College of Medicine, Kyung Hee University, Seoul, Korea. |
Vol.30 Num.6 (p545~550)
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Background : Outbreaks of infection as a result of contaminated antiseptics and
disinfectants have been reported. The major contaminants reported have been
Burkholderia cepacia, Pseudomonas aeruginosa, Xanthomonas maltophilia and
Pseudomonas fluorescens. A marked increase in the number of B. cepacia isolates was observed in a microbiology laboratory in Kyung Hee University Hospital. We
investigated an outbreak of pseudoinfection caused by benzalconium-chloride solution contaminated with B. cepacia.
Methods : We reviewed microbiology laboratory records from April 1996 to April 1997
to identify B. cepacia isolates and medical records of the patients from whom B. cepacia was cultured. Samples of 0.1% benzalconium solutions, benzalconium chloride-soaked cotton balls, specula, and forceps used in the outpatient department were examined.
Results : The majority was isolated from vaginal cultures in outpatients of gynecology department. The source of this outbreak was identified as the contaminated benzalconium-chloride solution. Investigation revealed that positive cultures were due to contamination of benzalconium-chloride solution and clinically insignificant in most cases. B. cepacia isolates were susceptible to ciprofloxacin and trimethopim-sulfamethoxazole, but the majority were resistant to gentamicin, ampicillin, cephalexin, and ampicillin-sulbactam.
Conclusion : It is necessary to check for microbial contamination of antiseptics and
disinfectants when an outbreak caused by B. cepacia is observed in hospital patients.
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Keywords : Burkholderia cepacia, Benzalconiumchloride, Pseudoinfection |
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