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 Original Articles |
| Changes in Antibody Titers of Measles, Mumps, Rubella, and Hepatitis B Virus After Bone Marrow Transplantation in Korea : A Preliminary Report |
| Lee SH, Choi SM, Park YH, Park SG, Kim YJ, Chung MS, Choi JH, Yoo JH, Shin WS, Min WS, Kim CC, Kim DJ |
| Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea. |
Vol.30 Num.6 (p558~563)
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Background : Bone marrow transplantation (BMT) has become a significant treatment modality for hematopoietic and solid organ malignancy. Recipients of BMTs lose immunity to measles-mumps-rubella (MMR) and hepatitis B infections which are preventable with vaccination. There is no consensus regarding a vaccination schedule after BMT and time of vaccination is variable according to each institution. We analyzed sequential changes in antibody titers of MMR and hepatitis B during the first year after BMT in an attempt to identify the time, dose, and needs for revaccination.
Methods : Total 20 patients with hematologic malignancies were studied. Serum levels of IgG antibodies of MMR and hepatitis B virus (HBV) were determined every three months post-BMT by enzyme immunoassay (EIA), chemical luminescence immunoassay (CLIA) and immunofluorescence assay (IFA).
Results : IgG antibody levels of measles, HBV were 1:746, 80±85 IU/mL, 214±343
IU/L before BMT, declined to 1:633, 18±11 IU/mL, 4±6 IU/L one year after BMT,
respectively. All the antibody levels were still above cut-off value for positive immunity. Mumps antibody titers were 1:62 before BMT, declined to 1:25 significantly from 6 months after BMT, but the antibody level was still above cut-off value.
Conclusion : Antibody titers of MMR and hepatitis B decline during the first year
after BMT, but the levels are still above cut-off value. Thus, the timing of
revaccination should be after the fast year post-transplantation. Long-term studies are needed to determine the optimal time for revaccination.
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Keywords : MMR, HBV, Bone marrow transplantation |
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