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 Case Reports |
| A Case of Congenital Rubella Syndrome |
| 1Jin Ho Yu, 1Young Ho Kwak/1He Sun Jung/1Song Yi Na/1Hoan Jong Lee/2Ki Joon Song |
| Department of Pediatrics, College of Medicine, Seoul National University. Department of Microbiology, College of Medicine, Korea University, Seoul, Korea. |
Vol.31 Num.5 (p439~444)
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Congenital rubella syndrome is a transplacental fetal infection with rubella virus and shows a wide spectrum of clinical expression from severe malformation to asymptomatic in the neonatal period. For the confirmation of congenital rubella, one of the following laboratory criteria should be present: isolation of rubella virus, demonstration of rubella-specific IgM antibody, or a rubella IgG antibody that persists and fails to drop at a rate of twofold dilution per month. Recently a reverse transcription-nested polymerase chain reaction(RT-nPCR) method for the prenatal diagnosis of rubella virus infection has been used. We experienced a case of congenital rubella in a 15-month old male who had suffered from
respiratory difficulty. He had low birth weight. Thrombocytopenia was noticed shortly after his birth. He was transferred to our hospital because persistent respiratory difficulty had been developing since the age of one month. His growth and development were delayed. Physical examination revealed micrognathia, hepatosplenomegly, Lymphadenopathy, and petechiae. Laboratory examination revealed a rubella specific IgM antibody. Chest X-ray suggested a chronic lung change. Rubella virus RNA was detected in the serum by RT-nPCR. This is the
first case of congenital rubella, which was confirmed by the detection ofrubella virus RNA, in Korea.
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Keywords : Congenital rubella, Reverse transcription-nested polymerase chain reaction |
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