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 Original Articles |
| A Prospective Multicenter Study on the Etiological Analysis of Community-Acquired Pneumonia in Adult Patients in Korea: Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae Infections |
| Cheol Hyun Joo, M.D.1, Ha Jung Yoon1, Jung Hyun Nam1, Mi Sun Moon1, Young Keol Cho, M.D.1, Jun Hee Woo, M.D.2, Jae Myung Kang, M.D.2, Wan Shik Shin, M.D.3, Yong Ree Kim, M.D.3, Min Ja Kim, M.D.4, Hee Jin Chung, M.D.4, Hoan Jong Lee, M.D.5 and Yoo Kyum Kim, M.D.1 |
| Department of Microbiology1, Internal Medicine2, College of Medicine, University of Ulsan, Department of Internal Medicine, College of Medicine, the Catholic University of Korea3, Korea University4, Deparment of Pediatrics5, College of Medicine, Seoul National University, Seoul, Korea |
Vol.33 Num.1 (p15~23)
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Background:The purpose of this study is to develop a rapid and sensitive method to detect M. pneumoniae and C. pneumoniae. In addition, we prospectively investigated the prevalence of M. pneumoniae and C. pneumoniae infections in community- acquired pneumonia.
Methods:The nasopharyngeal aspirates were collected from July 1997 to April 2000. PCR or nested PCR techniques were used to detect causative agents. RFLP and nucleotide sequence analysis were performed to study molecular epidemiology. Furthermore, feasibility of one-step technique to detect two microorganisms was tested by multiplex PCR.
Results:Of 250 clinical specimens, 23 (9.2%) specimens were positive for M. pneumoniae and 33 (13.2%) for C. pneumoniae, including one dual-infected specimen. Most M. pneumoniae infection occurred during the colder months of the year. C. pneumoniae infection was predominantly found from December to February.
Conclusion:The results indicate that M. pneumoniae and C. pneumoniae infections are frequently found from patients with community-acquired pneumonia. |
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Keywords : Community-acquired pneumonia, Mycoplasma pneumoniae, Chlamydia pneumoniae |
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