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 Original Articles |
| Frequency of Reistance to Aminoglycoside antibiotics in Staphylococcus Aureus Isolated from Tertiary Hospitals |
| Hong Bin Kim/Thoma Kim Bobin Lee/Ui Seok Kim/Sang Won Park/Jong Wook Shin/Myoung Don Oh/Eui Chong Kim/Yeong Seon Lee/Bong Su Kim/Kang Won Choe |
| Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea. |
Vol.34 Num.1 (p39~46)
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Background: Staphylococcus aureus is one of the most important pathogens, causing severe morbidity and fatal infections. To data rapid evolution of antibiotic resistance in S. aureus, including recent emergence of vancomycin-resistant S.
aureus (VRSA), has been a serious concern and an obstacle to the effective treatment. The purpose of this study is to update the resistance patterns against aminolycoside antibiotics which play an important role in the therapy of serious staphylococcal infectionas.
Methods: Clinical isolates were collected from 8 university-affiliated hospital during the period of June 1999 to January 2001. Susceptibility tests against 9 antibiotics were performed by disk diffusion method. Minimum inhibitory concentrations
(MICs) of arbekacin against non-susceptible strains were determined by microbroth dilution method.
Results: Among total 682 isolates exclusive of consecutive ones from the same patients, 199 (29%) were from pus, 152 (22%) from respiratory specimens, 137 (20%), from blood, 38 (6%) from urine. Of 682 isolates, 588 (87%) isolates were
resistant to at least one of the aminoglycosides tested. Overall prevalence of MRSA was 64% (439/682), and resistance rates of MRSA were summarized as follows; kanamycin (KM) 98%, tobramyciin (TOB) 98%, gentamicin (GM) 95%, amikacin (AMK) 90%, neomycin (NEO) 63%, streptomycin (SM) 31%, netilmicin (NET) 18%, arbekacin (ABK). MICs of ABK against 58 non-susceptible strains ranged from 2 to 128 ㎍/㎖.
Conclusion: More than 90% of MRSA isolates were resistant against kanamycin, tobramycin, gentamicin, and amikacin. Moreover, most of MRSA isolates wre multi-drug resistant to all these four aminoglycosides. Resistance rates against
arbekacin and netilmicin were less than 20%. Arbekacin was the most susceptible antibiotic of the aminoglycosides tested.
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Keywords : Stapjylococcus aureus, Aminoglycoside, Arbekacin |
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