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 Original Articles |
| Clinico-epidemiologic and Virologic Study of Measles Outbreak in Gwangju Metropolitan City During the 2000∼2001 epidemic |
| Byoung Kuk Na/Jae Keun Chung/Hyun Kyun Ki/Hye Young Ki/Sun Hee Kim/Young Hwa Jung/Ju MI Shin/Gu Choul Shin/Yoon Young Kim/Joo Yeon Lee/Jin Soo Lee/Chun Kang/Woo Joo Kim/Dong |
| Laboratory of Respiratory Viruses, National Institute of Health, Seoul, Korea. Department of Microbiology, Gwangju Institute of Health and Environment, Korea. |
Vol.34 Num.1 (p55~63)
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Background: Measles is a highly contagious disease caused by measles virus. Although the introductionof live attenuated measles vaccines has dramatically abrogated the endemic incidenced of measles cases and nearly one million deaths from measles annually. In this study, we characterized the measles outbreak in Gwangju Metropolitan city during the 2000∼2001 epidemic.
Methods: Study population included measles patients in Gwangju Metropolitan City from April, 2000 to May, 2001. We conducted a questionnaire survery on the patients and anlyzed the records based on the clinical guideline of World Health
Organization (WHO). Furthermore, we isolated the measles viruses from clinical specimens of patients and alalyzed the nucleotide sequences of nucleoprotein (N) gene.
Results: During the April 2000 to May 2001, measles epidemic, a total of 3,217 measles patients were reported in Gwangju Metropolitan city. The first patient of measles was reported on April, 2000. The incidence reachted its peak in
November, 2000. The decreased thereafter. The age distribution of the patients were various, which was ranged from 1 month after birth to 30 year adult and the peak incidence was observed at 7∼13 year old. Various complication s were developed in 232 patients and 2 of them died. Phylogenetic analyses of nucleotide
sequences and deduced amino acid sequences of the N genes of isolated viruses revealed that all viruses isolated in Gwangju Metropolitan city were grouped into the clade H1. This suggests that a single, predominant viral genotype was responsible
for the measles epidemic in Gwangju Metropolitan City.
Conclusion: In this study, we characterized the measle outbreak in Gwangju Metropolitan City during 2000∼2001. The measles outbreak in Gwangju Metropolitan City was considered to be caused by single genotype of measles virus (clade H1).
After a massive vaccination campaign among 7∼16 years old children to eliminate indigenous measles from this country, it is important to continue measles vaccination and intensive surveillance clinically as well as virologically.
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Keywords : Measles, Epidemic, Gwangju Metropolitan City |
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