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 Original Articles |
| In vitro Antimicrobial Susceptibility of Carbapenems, Including Panipenem, against Clinical Isolates in Korea |
| Dong-Gun Lee, M.D., Myungshin Kim, M.D.*, Jin-Han Kang, M.D.†, Hye-Sun Chun, M.S.‡, Su Mi Choi, M.D. Seoung-Heon Wie, M.D., Sang-Il Kim, M.D., Jung-Hyun Choi, M.D., Jin-Hong Yoo, M.D., Wan-Shik Shin, M.D. and Moon-Won Kang, M.D. |
| Department of Internal Medicine, Department of Clinical Pathology*, Department of Pediatrics†, Clinical Research Institute, St. Mary's Hospital‡, College of Medicine, The Catholic University of Korea, Seoul, Korea |
Vol.35 Num.2 (p91~98)
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Background : Panipenem (PAPM) is a new carbapenem which has an enhanced broad spectrum against both gram-positive and negative organisms. The aim of study was to compare the activities of PAPM with those of imipenem (IMPM), meropenem (MRPM) against several clinical isolates in Korea.
Methods : We tested the in vitro antimicrobial activities of PAPM, IMPM, and MRPM against total 300 clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa and 134 Streptococcus pneumoniae collected from 5 different university hospitals. Using NCCLS guidelines, MICs of PAPM, IMPM, MRPM, and/or ceftazidime were determined.
Results : All isolates of E. coli and K. pneumoniae were susceptible to PAPM, IMPM and MRPM. MIC90 of PAPM, IMPM, and MRPM against P. aeruginosa were 32, 16, and 8 μg/mL, respectively. Comparing Mueller-Hinton agar (MHA) and minimal agar Davis (MAD), the MIC90 of PAPM and IMPM were reduced from 16 and 32 μg/mL to 8 and 8 μg/mL, respectively. PAPM was more influenced by MAD than IMPM. All isolates of penicillin susceptible S. pneumoniae showed 0% of resistance to the carbapenems tested. MIC90 of PAPM, IMPM and PRPM against penicillin non-susceptible S. pneumoniae were 0.25, 1 and 2 μg/mL, respectively.
Conclusion : Panipenem could be one of the potentially useful drugs for the treatment of infections caused by E. coli, K. pneumoniae, and S. pneumoniae. We also showed that PAPM had good anti-pseudomonal activity when examined in MAD, the amino acid-limited media. Therefore, it could be useful for the treatment of infections caused by P. aeruginosa. |
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