Home > Available Issues
Original Articles
In Vitro Activities of Gatifloxacin against Bacteria isolated from Respiratory Specimens of Patients of University Hospitals in Korea
Dongeun Yong, M.D.*, Myungsook Kim, M.S.*, Sinyoung Kim, M.D.*, Kyungwon Lee, M.D.*,†, Sungkyu Kim, M.D.‡, Yunsop Chong, Ph.D.* and Yil Seob Lee, M.D.§
Department of Laboratory Medicine, Research Institute of Bacterial Resistance*, and Brain Korea 21 Medical Sciences†, Department of Internal Medicine‡, Yonsei University College of Medicine, Seoul, Korea, Handok Pharma Central Laboratory§, Seoul, Korea
Vol.36 Num.2 (p68~74)
Background:Gatifloxacin, a new 8-methoxyquinolone, has a broad-spectrum activity with expanded potency against respiratory pathogens. In this study, we examined the in vitro activity of gatifloxacin and comparators against recently isolated bacteria from respiratory specimens of patients in Korean hospitals.
Methods:Forty-nine isolates were from respiratory specimens of patients with acute exacerbations of chronic lower respiratory infections in eight university hospitals and 108 isolates were from respiratory specimens from patients of Yonsei University Hospital. Minimum inhibitory concentrations (MICs) were determined by NCCLS agar dilution method.
Results:MIC90 of gatifloxacin for Streptococcus pneumoniae was 1 ?g/mL, which was 8-fold and 2-fold lower than those of ciprofloxacin and levofloxacin, respectively. All strains of Haemophilus influenzae and Moraxella (Branhamella) catarrhalis were inhibited by ?0.06 ?g/mL and ?0.25 ?g/mL of gatifloxacin, respectively, and were susceptible to all fluoroquinolones tested. MIC90 of gatifloxacin for Klebsiella pneumoniae was 0.06 ?g/mL, which was 2-fold lower than those of levofloxacin and moxifloxacin.
Conclusion:Gatifloxacin is highly active against S. pneumoniae, H. influenzae and M. (B.) catarrhalis isolated from respiratory specimens of patients of university hospitals in Korea.
Keywords : Gatifloxacin, Respiratory tract pathogens, Acute exacerbation of chronic lower respiratory tract infection