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 Review Articles |
| Immunoreactivity of Iron-Repressible
Cell Wall Proteins and Exoproteins of
Staphylococcus aureus |
| Yong Lim, M.D.1, Jong Hoon Park, M.D.1, Seung IL Lee, M.D.2
Soo Young Cho, M.D.3 and Sung-Heui Shin, M.D.1,4 |
| Department of Microbiology1, Internal Medicine2 and Emergency Medicine3, and Research Center for Resistant Cells4,
Chosun University Medical School, Kwangju, Korea |
Vol.36 Num.4 (p241~244)
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In the present study, we tried to investigate immunoreactivity of iron-repressible cell wall proteins and exoproteins of Staphylococcus aureus when the convalescent serum obtained from the patient with septicemia was applied. On SDS-PAGE and western blot analysis, several iron-repressible cell wall proteins expressed in iron-deficient BHI showed strong immunoreactivity, whereas no or relatively weak immunoreactivity was shown in iron-sufficient BHI. Several exoproteins were expressed only in iron-deficient BHI and these exoproteins showed strong immunoreactivity. These results indicate that several iron-repressible cell wall proteins and exoproteins are expressed and are immunogenic in vivo. Since in vivo state is an relatively iron-restricted condition, we recommend the use of iron-deficient media for studies concerning pathogenicity of staphylococcal in human. |
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Keywords : ????, ?, ???? ?? |
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