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Pertussis as a Differential Diagnosis of Chronic Cough in Adults
Wan Beom Park, M.D.1, Sang Won Park, M.D.3, Ki-Deok Lee, M.D.1, Chang Seop Lee, M.D.1, Hee Chang Jang, M.D.1 Hong Bin Kim, M.D.1, Myoung-don Oh, M.D.1, Eui-Chong Kim, M.D.2 and Kang Won Choe, M.D.1
1Department of Internal Medicine, 2Department of Laboratory Medicine, College of Medicine, Seoul National University, Seoul 3Department of Internal Medicine, College of Medicine, Dankook University, Cheonan, Korea
Vol.36 Num.6 (p331~334)
Background:Pertussis was long considered a childhood illness. However, in the last two decades, it has been reported as a cause of prolonged cough in adolescents and adults in other countries. Infection of Bordetella pertussis was prospectively searched among adults with a persistent cough.
Materials and Methods:Adult patients, who visited either the outpatient clinic of a municipal hospital or a university health service center due to cough of more than six days' duration without underlying pulmonary disease, from September 2002 to May 2003, were enrolled. The culture and polymerase chain reaction (PCR) were used for confirming of B. pertussis infection.
Results:102 adult patients with persistent cough were evaluated. 3 (2.9%) patients were PCR positive for B. pertussis. There were no patients with positive culture. All patients with positive PCR had one or more classic symptoms of pertussis and their cough persisted for 3-7 weeks.
Conclusion:We confirmed the morbidity of pertussis in Korean adults with persistent cough. Pertussis should be considered as a differential diagnosis of chronic cough in adults.
Keywords : Bordetella pertussis, Adult, Cough, Polymerase chain reaction