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Drug Use Evaluation of Intravenous Ciprofloxacin in University Hospitals in Korea
Shin-Woo Kim1, Hyo Jung Park2, Won Sup Oh3, Yeon Sook Kim4, Hyun Ha Chang5, Sook In Jung6 Doo Ryeon Chung7, Hyuck Lee8, Joon Sup Yeom9, Hyun Kyun Ki3, Jun Seong Son3, Kyong Ran Peck3, Gun-Jo Woo10 and Jae-Hoon Song3
Division of Infectious Diseases1, Kyungpook National University Hospital, Daegu, Korea Division of Pharmaceutical Services2 and Division of Infectious Diseases3, Samsung Medical Center, Sungkyunkwan University Medical School, Seoul, Korea Division of Infe
Vol.36 Num.6 (p350~356)
Background:To evaluate the appropriateness of intravenous (IV) ciprofloxacin usage in university hospitals in Korea.
Materials and Methods:We prospectively evaluated the appropriateness of drug usage in 290 consecutive adult patients who received IV ciprofloxacin in eight teaching hospitals during the period from September 25, 2003 to November 15, 2003. Drug use evaluation (DUE) in this study was based on the modified standard by the American Society of Hospital Pharmacy with regard to the justification of drug use, critical and process indications, complications, and outcome measures.
Results:Average age of the patients was 54 years. The use of IV ciprofloxacin was appropriate only in 33 cases (26.9%). Common reasons for inappropriate use of IV ciprofloxacin include perioperative uses or prophylactic injection before urologic procedures, and empirical therapy for febrile episodes. Most of the "critical indications" and "process indications" showed high rate of appropriateness (82.4-100%). However, the rate of taking culture and sensitivity test before (73.8%) and during ciprofloxacin use (68.6%) were low. Complications with ciprofloxacin use were rare. In 93.3% of cases, ciprofloxacin treatment was clinically effective.
Conclusion:Use of intravenous ciprofloxacin is frequently inappropriate in tertiary care hospitals in Korea. Implementation of education program and antibiotic control system is critical in improving the appropriateness of antimicrobial use.
Keywords : Drug use evaluation, Ciprofloxacin