|
 |
 Home > Available Issues |
|
|
 Original Articles |
| Multi-center Study on Cost Effectiveness of Anti-Tuberculosis Drug Susceptibility Test |
| Seok Hoon Jeong, M.D.1, Dae Dong Lee, M.D.2, Jae-Cheol Choi, M.D.2, Sunjoo Kim, M.D.3, Jeong Hwan Shin, M.D.4Joseph Jeong, M.D.5, Eun Yup Lee, M.D.2, Seung Hwan Oh, M.D.2, Gill-Han Bai, Ph.D.6, Chulhun L. Chang, M.D.2,6,7 |
| 1Department of Laboratory Medicine, Kosin University College of Medicine, Busan2Department of Laboratory Medicine, College of Medicine, Pusan National University, Busan3Department of Laboratory Medicine, School of Medicine, Gyeongsang National Universit |
Vol.37 Num.1 (p16~21)
|
|
|
Background:The anti-mycobacterial susceptibility test is performed on only a small percentage of clinical isolates in Korea. The aim of this study is to propose an anti-mycobacterial susceptibility testing scheme, which is not only economic and practical but also fully informative to physicians.
Materials and Methods:The anti-mycobacterial susceptibility test results of 502 strains, isolated from five university-affiliated hospitals, were analysed. The interpretation of the results and the need for second-line drug susceptibility test were judged according to the recommendation of NCCLS M24-A guidelines.
Results:The isolates from 10% (38/363) of treatment-navie patients and 61% (85/139) of re- treatment patients showed resistance to at least one of the anti-mycobactial agents; 3% (11/363) and 44% (61/139) of isolates from each group were multi-drug resistant. According to the recommendation by NCCLS, the percentage of patients not needing the susceptibility test results for second-line drugs were 96% for treatment-naive and 47% for re-treatment patients.
Conclusion:Since the susceptibility test against first-line drug is sufficient for 95% of treatment- navie patients with tuberculosis patients, susceptibility test against second-line drugs may be performed only when it is necessary. As for the re-treatment patients with tuberculosis, susceptibility test for both first-line and second-line drugs should be performed simultaneously. |
|
|
Keywords : Mycobacterium tuberculosis, Anti-tuberculosis susceptibility test, Cost effectiveness |
|
|
|
|
|
|
|
|
