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 Original Articles |
| In Vitro Activity of Cefditoren against Respiratory Pathogens |
| Joon Young Song, M.D.1, Yu Mi Jo, M.D.1, Won Suk Choi, M.D.1, Sae Yoon Kee, M.D.1, Cheong Won Park, M.D.1In Sook Hwang, M.S.1, Jong Jin Hyun, M.D.1, Jang Wook Sohn, M.D.1, Chang Gyu Lee, M.D.2Hee Jin Cheong, M.D.1, Woo Joo Kim, M.D.1, and Min Ja Kim, M. |
| Division of Infectious Disease, Departments of Internal Medicine1, Department of Clinical Microbiology2Korea University College of Medicine, Seoul, Korea |
Vol.37 Num.3 (p138~143)
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Background:Cefditoren is a third generation orally administered cephalosporin with excellent activity against respiratory pathogens. This study was performed to determine the comparative antibacterial activity of cefditoren against clinical isolates of respiratory tract infection.
Materials and Methods:According to the NCCLS guideline, in vitro activities of cefditoren and other antibiotics were tested against respiratory pathogens including 117 isolates of Streptococcus pneumoniae, 60 isolates of Haemophilus influenzae, and 31 isolates of Moraxella catarrhalis.
Results:The level of cefditoren activity against S. pneumoniae (MIC50/90, 0.5/1 μg/mL) was superior to amoxicillin±clavulanate (MIC50/90, 4/16 μg/mL), clarithromycin (MIC50/90, >32/>32 μg/mL), and most of the marketed cephalosporins (MIC50/90, 8-64/16-128 μg/mL). Although the MIC of cefditoren was relatively higher than those of new Ŧ??? |
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Keywords : Cefditoren, Respiratory tract pathogens, Antibiotic susceptibility |
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