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Original Articles
Antibacterial Effect of Lidocaine, Thrombin, and Epinephrine
Jin-Woo Kim, M.D.1, Dong-Gun Lee, M.D.2, Hye-Sun Chun, M.S.2, Seung-Joon Kim, M.D.1 Seok-Chan Kim, M.D.1, Joong-Hyun Ahn, M.D.1, Chi-Hong Kim, M.D.1, Soon-Seog Kwan, M.D.1 Young-Kyoon Kim, M.D.1, Kwan-Hyoung Kim, M.D.1, Hwa-Sik Moon, M.D.1, Wan-Shik Shin,
Division of Respiratory Diseases1, Division of Infectious Diseases2, Department of Internal Medicine, Catholic Research Institute of Medical Science3, College of Medicine, The Catholic University of Korea, Seoul, Korea
Vol.37 Num.6 (p345~349)
Background:We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures.
Materials and Methods:The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards.
Result:MIC50 and MIC90 of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ?g/mL and that for K. pneumoniae were 10,000 ?g/mL. MIC50 and MIC90 of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC50 and MIC90 of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ?g/mL; that for S. aureus and P. aeruginosa were 500 ?g/mL.
Conclusion:We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.
Keywords : Lidocaine, Thrombin, Epinephrine, Antibacterial effect