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A Case of Disseminated Scedosporium apiospermum Infection in a Liver Transplant Patient
Hyun-Gu Park, M.D., Seong-Ho Choi, M.D., Ho Suk Kang, M.D., Ju Hyung Song, M.D., Ji Hoon Jung, M.D.Min Wook So, M.D., Sang-Ho Choi, M.D., Yang Soo Kim, M.D. and Jun-Hee Woo, M.D.
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Vol.38 Num.5 (p290~295)
Sedosporium apiospermum is a saprophytic fungus commonly found in soil and polluted water. This organism is known as a cause of mycetoma, which may occur in immunocompetent hosts following trauma. However, in immunocompromised patients, S. apiospermum can also cause life-threatening invasive disease, including central nervous system infection or disseminated infection. We report a fatal case of disseminated S. apiospermum infection in a 46-year-old woman after liver transplantation. Eight days postoperatively, she developed pneumonia, followed by altered mentality in the 15 days. A head CT demonstrated multiple brain abscesses. Sputum and stereotactic-aspirated brain abscess culture yielded S. apiospermum. Despite treatment with voriconazole, the patient died of intracranial hemorrhage.
Keywords : Scedosporium apiospermum, Liver transplantation, Voriconazole