|
 |
 Home > Available Issues |
|
|
 Original Articles |
| In Vitro Activities of Isepamicin and Other Aminoglycosides against Gram-Negative Organisms |
| Hyun-Hee Kwon, M.D.1,3, Su Jin Park1,3, Min Wook So, M.D.1, Hyun-Gu Park, M.D.1,3, Seong-Ho Choi, M.D.1,3Mi-Na Kim, M.D.2, Sang-Ho Choi, M.D.1,3, Jin-Yong Jeong, Ph.D.1,3, Jun Hee Woo, M.D.1,3 and Yang Soo Kim, M.D.1,3 |
| Department of Internal Medicine1, Laboratory Medicine2, Asan Medical Center, University of Ulsan College of Medicine, Center for Antimicrobial Resistance and Microbial Genetics3, University of Ulsan, Seoul, Korea |
Vol.38 Num.6 (p356~361)
|
|
|
Background:The increasing incidence of multidrug-resistant gram-negative bacteria causing nosocomial infections is an important clinical problem. Isepamicin is a recently developed aminoglycoside which has been known to have potent activity against gram-negative organisms. We evaluated the in vitro activities of isepamicin and other aminoglycosides against a large number of gram-negative organisms.
Materials and Methods:We tested the in vitro antimicrobial activities of isepamicin, amikacin, gentamicin, and tobramycin against 566 gram-negative organisms collected between January 2006 and June 2006 in Asan Medical Center. Minimal inhibitory concentrations (MICs) were determined and interpreted according to the recommendations of Clinical and Laboratory Standard Institute (CLSI). The breakpoint MIC used for interpretation of isepamicin was MIC≤16 μg/mL as 7 |
|
|
Keywords : Aminoglycosides, Gentamicin, Tobramycin, Amikacin, Isepamicin |
|
|
|
|
|
|
|
|
