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A Case of Cytomegalovirus Enterocolitis and Jejunal Perforation During Immune Reconstitution with Highly Active Antiretroviral Treatment
Se Ho Choi, M.D.1, Hyo Sung Kang, M.D.1, Sung Ho Lee, M.D.1, Jong Hyun Lee, M.D.1, Kyung Youn Seon, M.D.1 Seung Woo Nam, M.D.1, Jae kwan Hwang, M.D.2 and Hyoung Shik Shin, M.D.1
Departments of Internal Medicine1, General Surgery2, National Medical Center, Seoul, Korea
Vol.38 Num.6 (p398~402)
Immune reconstitution syndrome (IRS) in HIV-infected patients is an adverse consequence of the restoration of pathogen-specific immune responses during the initial months of highly active antiretroviral treatment(HAART). Previously subclinical infections are unmasked or pre-existing opportunistic infections clinically deteriorate as host immunopathological inflammatory responses are switched on. While the eye is the area where Cytomegalovirus(CMV)-associated IRS occurs most often in patients with AIDS, it also can present with intestinal or pulmonary involvement. We present a case report of an HIV-infected patient in whom CMV enterocolitis and jejunal perforation developed after HAART.
Keywords : Cytomegalovirus, Enterocolitis, Immune reconstitution syndrome, Highly active antiretroviral therapy