Home > Available Issues
Original Articles
The Association between CD14 Polymorphism and Response to Infectious Agents orHeat Shock Protein in Patients with Stable Coronary Artery Disease in Koreans
Joo-Yong Hahn, M.D.1,3, Soo-Yeon Choi, M.D.1,2, Hyun-Ju Cho, M.S.3, Hwa-Pyung Kim, M.S.3Hyun-Jae Kang, M.D.1,3, Bon-Kwon Koo, M.D.1,3, Nam Joong Kim, M.D.1, Hyo-Soo Kim, M.D.1,3Dae-Won Sohn, M.D.1,3, Byung-Hee Oh, M.D.1,2,3, Young-Bae Park, M.D.1,3 and
1Department of Internal Medicine, Seoul National University College of Medicine2Gangnam Center, Seoul National University Hospital, 3Cardiovascular Research Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
Vol.39 Num.1 (p17~23)
Background:CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans.
Materials and Methods:Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured.
Results:Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L).
Conclusions:This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans.
Keywords : CD14, Chlamydia pneumoniae, Helicobacter pylori, Heat shock protein; Coronary artery disease