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 Original Articles |
| Relationship between β-Lactam Antimicrobial Use and Antimicrobial resistance in Klebsiella pneumoniae Clinical Isolates at 5 Tertiary Hospitals in Korea |
| Sook-In Jung, M.D.1, Kyung-Hwa Park, M.D.1, Ki Tae Kwon, M.D.2, Kwan Soo Ko, M.D.2, Won Sup Oh, M.D.2, Doo Ryeon Chung, M.D.2, Kyong Ran Peck, M.D.2, Joon Sup Yeom, M.D.3, Hyun Ha Chang, M.D.4, Shin-Woo Kim, M.D.4, Jun Seong Son, M.D.5, and Jae-Hoon Song, M.D.2 |
| Division of Infectious Diseases1, Chonnam National University Medical School, Gwangju; Division of Infectious Diseases2, Samsung Medical Center, Sungkyunkwan University Medical School, Seoul; Division of Infectious Diseases3, Kangbuk Samsung Hospital, Sungkyunkwan University Medical School, Seoul; Division of Infectious Diseases4, Kyungpook National Univeristy Hospital, Daegu; Division of Infectious Diseases5, Chungbuk National University Hospital, Chungju, Korea |
Vol.39 Num.4 (p189~195)
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Background:This study was performed to evaluate the prescribing pattern of β-lactam antibiotics and the relationship between antimicrobial resistance and antimicrobial use in 5 tertiary care hospitals in Korea.
Materials and Methods:Data on annual patient-days and annual consumption (defined daily dose (DDD) per 100 patient-days) of β-lactam antibiotics from 2003 to 2005 in 5 tertiary hospitals were analyzed. To determine the antimicrobial resistance in K. pneumoniae, broth microdilution test and double disk synergy were performed according to the CLSI performance standards. Spearman's correlation coeffient was used to determine the relationship between antibiotic consumption and resistance.
Results:The prescription of β-lactam antibiotics in 5 tertiary hospitals markedly varied. In two hospitals, increase in consumption of β-lactam antibiotics was more than 30% during recent 3 years. The higher consumption of β-lactam antibiotics significantly correlated with the higher rate of antibiotic-resistant K. pneumoniae in 5 tertiary care hospitals.
Conclusion:Continuous surveillance of antibiotic use is needed to encourage appropriate prescribing of antibiotics and to reduce antibiotic resistance
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Keywords : β-lactam antibiotics, Antibiotic use, Antibiotic resistance |
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