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Case Reports
A Case of Good's Syndrome
Kyoung-Ho Song, M.D.1, Kye Hyung Kim, M.D.1, Chung-Jong Kim, M.D.1, Kyoung Un Park, M.D.2, Sanghoon Jheon, M.D.3, Hong Bin Kim, M.D.1 , Nam Joong Kim, M.D.1, Myoung-don Oh, M.D.1 and Kang Won Choe, M.D.1
Department of Internal medicine1, Laboratory medicine2, Thoracic and Cardiovascular Surgery3 Seoul National University College of Medicine
Vol.39 Num.5 (p259~262)
Good's syndrome is the association of thymoma with immunodeficiency, characterized by hypogammaglobulinemia, B-cell lymphopenia and variably defects in cellular immunity with CD4? T-cell lymphopenia and an inverted CD4?:CD8? T-cell ratio. We report a 43-year-old male patient who presented with a 18-month history of productive cough and postnasal drip. One year ago, he underwent the operation for resection of a thymoma. Despite of appropriate management, sinusitis relapsed multiple times. He was found to have hypogammaglobulinemia with nearly absent B cells(4/?L). The CD4? T-cell count was 554/?L with an inverted CD4?:CD8? T-cell ratio of 0.6. His symptoms and signs improved with antibiotic treatment and monthly administration of intravenous immunoglobulin (IVIG, 400 mg/kg).
Keywords : Good syndrome, Thymoma, Immunodeficiency, Hypogammaglobulinemia